A simple method for statistical analysis of intensity differences in microarray-derived gene expression data

BMC Biotechnology

Table 1 Genes whose expression differs significantly from controls

Method	Cutoff	Cad5CD		TcfDN		Both		Total	Total
		Only		Only					(Same Sign)
		Up	Down	Up	Down	Up	Down
Ratio	1.7	0	4	0	0	0	1	5	5
Diff.	3.0	5	12	9	26	2	15	69	66

Genes whose expression differs significantly from controls analyzed either by either by ratio or by the difference-averaging method (diff.). All 5 genes in the ratio set are present in the diff. set (see results). "Cutoff" is an intesity ratio for "Ratio" and a z value for "Diff." "Both" encompasses genes that are up- or down-regulated in both datasets (Cad5CD and TcfDN) for |z|>3.

ISSN: 1472-6750